ABSTRACT
Background: This study is aimed at evaluating the levels of some trace elements and testosterone, and to ascertain their possible association in type 2 diabetes mellitus. Methods: Ninety male type 2 diabetic subjects and forty five apparently healthy non-diabetic male individuals were recruited into this study. The control group was matched for age with the study subjects and they were all within the age range of 30-67 years. Fasting Plasma Glucose (FPG), testosterone, trace elements (zinc, selenium, manganese), Body Mass Index (BMI) were determined. Results: This study showed significant decreases in the levels of trace elements (Zn, Se, and Mn) with a concomitant decrease in the levels of testosterone in type 2 diabetic patients (P <0.001). This findings were further strengthened by the strong positive correlation between testosterone and these trace elements (P <0.05). Conclusion: This suggests that low testosterone level might be as a result of low trace elements considering their role in testosterone production. Therefore, trace elements supplementation is recommended.
ABSTRACT
Aim: The serum trace elements statuses of sickle cell patients attending at General Hospital Owerri, Nigeria were investigated to determine whether or not the serum levels of these elements were normal. Materials and Methods: One hundred confirmed sickle cell patients (HbSS) age 5–30 years were selected. One hundred normal subjects (HbAA) age 5–30 years were used as control. Results: The levels of trace elements were significantly decreased in sickle cell anemia (p<0.05), except copper, when compared with the control. Conclusion: The result suggests, but not conclusively, that supplementation of sickle cell patients with food and drug containing trace elements might be helpful, particularly if diminished mineral levels predispose patients to crises.